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Essential role of nucleotide diphosphates in nicorandil-mediated activation of cardiac ATP-sensitive K+ channel.

Shen WK, Tung RT, Machulda MM, Kurachi Y.

Activation of ATP-sensitive K channels by a K channel opener (SR 44866) and the effect upon electrical and mechanical activity of frog skeletal muscle.

Sauviat MP, Ecault E, Faivre JF, Findlay I.

Potassium channel activity in sarcolemmal vesicles formed from skeletal muscle fibres of normal and dystrophic mice. K+ channel openers suppress myotonic activity of human skeletal muscle in vitro.

Quasthoff S, Spuler A, Spittelmeister W, Lehmann-Horn F, Grafe P.

Effect of cromakalim and lemakalim on slow waves and membrane currents in colonic smooth muscle.

Post JM, Stevens RJ, Sanders KM, Hume JR.

Dual effects of ATP on K+ currents of mouse pancreatic beta-cells. Adenosine triphosphate-sensitive potassium channels in the cardiovascular system.

The antihypertensive property of NIP-121, a novel potassium channel opener in rats.

Masuda Y, Arakawa C, Yokoyama T, Shigenobu K, Tanaka S.

Dual effects of calcium on ATP-sensitive potassium channels of frog skeletal muscle. Dual effects of diazoxide on ATP-K+ currents recorded from an insulin-secreting cell line. Effects of lemakalim on changes in Ca2+ concentration and mechanical activity induced by noradrenaline in the rabbit mesenteric artery.

Ito S, Kajikuri J, Itoh T, Kuriyama H.

Influence of lemakalim on the pulmonary vascular bed of the cat. Hyperpolarization of denervated skeletal muscle by lemakalim and its antagonism by glybenclamide and tolbutamide.

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches.

Hamill OP, Marty A, Neher E, Sakmann B, Sigworth FJ.

Modulation by Mg2+ and ADP of ATP-sensitive potassium channels in frog skeletal muscle. ATP maintains ATP-inhibited K+ channels in an operational state. Calcium-dependent inactivation of the ATP-sensitive K+ channel of rat ventricular myocytes. Multiple actions of pinacidil on adenosine triphosphate-sensitive potassium channels in guinea-pig ventricular myocytes. The potassium channel opener cromakalim (BRL 34915) activates ATP-dependent K+ channels in isolated cardiac myocytes.

Escande D, Thuringer D, Leguern S, Cavero I.

Potassium selective ion channels in insulin-secreting cells: physiology, pharmacology and their role in stimulus-secretion coupling. The effect of intracellular pH on ATP-dependent potassium channels of frog skeletal muscle. ATP-dependent potassium channels of muscle cells: their properties, regulation, and possible functions. Effect of channel blockers on potassium efflux from metabolically exhausted frog skeletal muscle. Cromakalim and lemakalim activate Ca(2+)-dependent K+ channels in canine colon.

Carl A, Bowen S, Gelband CH, Sanders KM, Hume JR.

Potassium channels and airway function: new therapeutic prospects. Activation of ATP-sensitive K channels in heart cells by pinacidil: dependence on ATP. Nucleotide diphosphates activate the ATP-sensitive potassium channel in mouse skeletal muscle. Links to PubMed are also available for Selected References. Get a printable copy (PDF file) of the complete article (1.7M), or click on a page image below to browse page by page.

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Full textДЇull text is available as a scanned copy of the original print version. Results show that BRL 38227 caused direct activation of K+ATP in skeletal muscle and that this was mediated through a magnesium-dependent binding site rather than alleviation of inhibition by competitive displacement of ATP from the inhibitory site. BRL 38227 and 5 microM MgATP failed to activate channels following complete run-down. BRL 38227 also caused activation of K+ATP channels in the presence of low (< 100 microM) but not high (1.0 mM) ATP, particularly in patches containing large numbers of channels. The degree of activation diminished with successive applications of BRL 38227. In the absence of ATP at the cytoplasmic side of excised inside-out patches, BRL 38227 caused direct and magnesium-dependent activation of K+ATP channels. Linear slope conductance of the inward current, partial rectification of the outward current and glibenclamide sensitivity indicate that K+ATP channels are the site of action of BRL 38227. In cell-attached patches BRL 38227 (100 microM) caused activation of a glibenclamide-sensitive potassium current. Investigations were made into the effects of BRL 38227, a potassium channel activator, on ATP-sensitive potassium channels (K+ATP channels) in single fibres dissociated from the flexor digitorum brevis muscle of C57BL/6J mice.